Not being able to reduce the gap with practice, which implies that knowledge generated by design research is useless for design practice. We hardly see practical designers in design research conferences or design researchers in professional conferences.
Not being able to develop a designerly way of methods. Designers are still relying on methods borrowed from other disciplines, which makes methods difficult to apply to design problems.
Not being able to catch up with new technologies and social paradigms such as IoT or crowd sourcing. Different technologies and users require different types of knowledge, methods, and processes.